Bone Targeting Nanoparticles for the Treatment of Osteoporosis.
Int J Nanomedicine
; 19: 1363-1383, 2024.
Article
en En
| MEDLINE
| ID: mdl-38371454
ABSTRACT
Osteoporosis (OP) affects millions of people worldwide, especially postmenopausal women and the elderly. Although current available anti-OP agents can show promise in slowing down bone resorption, most are not specifically delivered to the hard tissue, causing significant toxicity. A bone-targeted nanodrug delivery system can reduce side effects and precisely deliver drug candidates to the bone. This review focuses on the progress of bone-targeted nanoparticles in OP therapy. We enumerate the existing OP medications, types of bone-targeted nanoparticles and categorize pairs of the most common bone-targeting functional groups. Finally, we summarize the potential use of bone-targeted nanoparticles in OP treatment. Ongoing research into the development of targeted ligands and nanocarriers will continue to expand the possibilities of OP-targeted therapies into clinical application.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteoporosis
/
Resorción Ósea
/
Nanopartículas
Límite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Int J Nanomedicine
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Nueva Zelanda