CASM mediates LRRK2 recruitment and activation under lysosomal stress.
Autophagy
; 20(7): 1692-1693, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38497477
ABSTRACT
Conjugation of ATG8 to single membranes (CASM) at endolysosomal compartments has attracted attention as the non-autophagic function of the Atg8-family protein conjugation system, and the V-ATPase-ATG16L1 axis has emerged as a core mechanism. Our recent research has revealed that this mechanism contributes to the lysosomal recruitment and activation of LRRK2, a Parkinson disease-associated kinase that phosphorylates a subset of RAB GTPases. The activated LRRK2 under CASM-causing lysosomal stress acts to regulate lysosomal morphology and stimulate extracellular secretion of lysosomal contents, thereby promoting the lysosomal stress response.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina
/
Lisosomas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Autophagy
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Estados Unidos