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[Correlation between CRAB Symptoms and Antioxidant Enzyme Activity in Patients with Multiple Myeloma].
Zhang, Xiao-Xu; Zhang, You-Zhi; Ma, Yu-Shuo; Wang, Wei.
Afiliación
  • Zhang XX; Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao 266000,Shandong Province, China.
  • Zhang YZ; Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao 266000,Shandong Province, China.
  • Ma YS; Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao 266000,Shandong Province, China.
  • Wang W; Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao 266000,Shandong Province, China.E-mail: 18661807392@163.com.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 32(2): 493-498, 2024 Apr.
Article en Zh | MEDLINE | ID: mdl-38660857
ABSTRACT

OBJECTIVE:

To investigate the relationship between clinical indicators of CRAB symptoms and antioxidant enzyme activity in patients with multiple myeloma (MM).

METHODS:

The activity of catalase (CAT), glutathione peroxidase (GPX), and superoxide dismutase (SOD) in the bone marrow supernatants of 44 patients with MM and 12 patients with non-malignant hematological diseases was detected by colorimetric assay, and then the differences in the activity of antioxidant enzymes between the two groups were compared. Furthermore, the relationship between the activity of antioxidant enzymes in the MM group and the levels of serum calcium, serum creatinine (Scr), hemoglobin (Hb), alkaline phosphatase (ALP) as well as bone lesions were analyzed.

RESULTS:

The antioxidant enzyme activity was lower in MM patients compared with the control group (P < 0.05). When the concentrations of serum calcium and ALP were higher than the normal levels, Hb was lower than 85 g/L, and there were multiple bone lesions, the activity of CAT, SOD and GPX was significantly declined (P < 0.05); When the concentration of Scr≥177 µmol/L, the activity of GPX was significantly declined (P < 0.05). Regression analyses showed that CAT, SOD and GPX were negatively correlated with serum calcium (r =-0.538, r =-0.456, r =-0.431), Scr (r =-0.342, r =-0.384, r =-0.463), and ALP (r =-0.551, r =-0.572, r =-0.482).

CONCLUSION:

The activity of antioxidant enzymes, including CAT, SOD and GPX, were decreased in patients with MM and they were negatively correlated with some clinical indicators of CRAB symptoms (such as serum calcium, Scr, and ALP), which suggests that promoting the activity of antioxidant enzymes may be beneficial to treat the CRAB symptoms of the patients with MM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mieloma Múltiple / Antioxidantes Límite: Humans Idioma: Zh Revista: Zhongguo Shi Yan Xue Ye Xue Za Zhi Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mieloma Múltiple / Antioxidantes Límite: Humans Idioma: Zh Revista: Zhongguo Shi Yan Xue Ye Xue Za Zhi Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China