S100 protein family: Emerging role and mechanism in digestive tract cancer (Review).
Int J Oncol
; 64(6)2024 06.
Article
en En
| MEDLINE
| ID: mdl-38666531
ABSTRACT
Digestive tract cancer is one of the most common types of cancers globally, with ~4.8 million new cases and 3.4 million cancerassociated deaths in 2018, accounting for 26% of cancer incidence and 35% of cancerrelated deaths worldwide. S100 protein family is involved in regulating cancer cell proliferation, angiogenesis, epithelialmesenchymal transition (EMT), metastasis, metabolism and immune microenvironment homeostasis. The critical role of S100 protein family in digestive tract cancer involves complicated mechanisms, such as cancer stemness remodeling, anaerobic glycolysis regulation, tumorassociated macrophage differentiation and EMT. The present study systematically reviewed published studies on the compositions, function and the underlying molecular mechanisms of the S100 family, as well as guidance for diagnosis, treatment and prognosis of digestive tract cancer. Systematic review of the roles and underlying molecular mechanisms of S100 protein family may provide new insight into exploring potential cancer biomarkers and the optimized therapeutic strategies for digestive tract cancer.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas S100
/
Biomarcadores de Tumor
/
Transición Epitelial-Mesenquimal
Límite:
Humans
Idioma:
En
Revista:
Int J Oncol
Asunto de la revista:
NEOPLASIAS
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Grecia