Electrokinetic Desalting and Salting of Water-in-Oil Droplets.
Anal Chem
; 96(24): 9876-9884, 2024 Jun 18.
Article
en En
| MEDLINE
| ID: mdl-38842795
ABSTRACT
Droplet-based microfluidic platforms demand modifications to the droplet composition to facilitate reactions and analyses. However, limited techniques exist to modify the droplet contents post their generation. Here, ion transport across two ion-exchange membranes possessing distinct selectivity is employed to introduce ions into (salt) or extract ions from (desalt) water-in-oil droplets. The ion concentration distribution and transport mechanisms are visualized using a precipitation reaction and a charged fluorescent tracer. Furthermore, current measurements reveal characteristic regimes in desalting and salting modes and demonstrate that the rates of ion transport linearly correlate with applied voltage and the ionic strength of the droplets. Importantly, up to 98% desalting efficiency is achieved. This technique advances droplet-based sample preparation through the straightforward manipulation of droplet contents.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Anal Chem
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos