Effects of endurance training under calorie restriction on energy substrate metabolism in mouse skeletal muscle and liver.
J Physiol Sci
; 74(1): 32, 2024 Jun 07.
Article
en En
| MEDLINE
| ID: mdl-38849720
ABSTRACT
We investigated whether calorie restriction (CR) enhances metabolic adaptations to endurance training (ET). Ten-week-old male Institute of Cancer Research (ICR) mice were fed ad libitum or subjected to 30% CR. The mice were subdivided into sedentary and ET groups. The ET group performed treadmill running (20-25 m/min, 30 min, 5 days/week) for 5 weeks. We found that CR decreased glycolytic enzyme activity and monocarboxylate transporter (MCT) 4 protein content, while enhancing glucose transporter 4 protein content in the plantaris and soleus muscles. Although ET and CR individually increased citrate synthase activity in the plantaris muscle, the ET-induced increase in respiratory chain complex I protein content was counteracted by CR. In the soleus muscle, mitochondrial enzyme activity and protein levels were increased by ET, but decreased by CR. It has been suggested that CR partially interferes with skeletal muscle adaptation to ET.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Condicionamiento Físico Animal
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Músculo Esquelético
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Transportadores de Ácidos Monocarboxílicos
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Restricción Calórica
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Metabolismo Energético
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Hígado
Límite:
Animals
Idioma:
En
Revista:
J Physiol Sci
Asunto de la revista:
FISIOLOGIA
/
TRAUMATOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Japón