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Extracellular Matrix Structure and Interaction with Immune Cells in Adult Astrocytic Tumors.
Di Vito, Anna; Donato, Annalidia; Bria, Jessica; Conforti, Francesco; La Torre, Domenico; Malara, Natalia; Donato, Giuseppe.
Afiliación
  • Di Vito A; Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy. divito@unicz.it.
  • Donato A; Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
  • Bria J; Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy.
  • Conforti F; Pathology Unit, "Annunziata" Hospital, Cosenza, Italy.
  • La Torre D; Unit of Neurosurgery, Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
  • Malara N; Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
  • Donato G; Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Cell Mol Neurobiol ; 44(1): 54, 2024 Jul 05.
Article en En | MEDLINE | ID: mdl-38969910
ABSTRACT
The extracellular matrix (ECM) is a dynamic set of molecules produced by the cellular component of normal and pathological tissues of the embryo and adult. ECM acts as critical regulator in various biological processes such as differentiation, cell proliferation, angiogenesis, and immune control. The most frequent primary brain tumors are gliomas and by far the majority are adult astrocytic tumors (AATs). The prognosis for patients with these neoplasms is poor and the treatments modestly improves survival. In the literature, there is a fair number of studies concerning the composition of the ECM in AATs, while the number of studies relating the composition of the ECM with the immune regulation is smaller. Circulating ECM proteins have emerged as a promising biomarker that reflect the general immune landscape of tumor microenvironment and may represent a useful tool in assessing disease activity. Given the importance it can have for therapeutic and prognostic purposes, the aim of our study is to summarize the biological properties of ECM components and their effects on the tumor microenvironment and to provide an overview of the interactions between major ECM proteins and immune cells in AATs. As the field of immunotherapy in glioma is quickly expanding, we retain that current data together with future studies on ECM organization and functions in glioma will provide important insights into the tuning of immunotherapeutic approaches.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Astrocitoma / Matriz Extracelular / Microambiente Tumoral Límite: Adult / Animals / Humans Idioma: En Revista: Cell Mol Neurobiol Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Astrocitoma / Matriz Extracelular / Microambiente Tumoral Límite: Adult / Animals / Humans Idioma: En Revista: Cell Mol Neurobiol Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos