Association between exposure to organophosphate pesticides and cytokine levels in a population of flower workers in Mexico.
Environ Toxicol Pharmacol
; 110: 104521, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-39069195
ABSTRACT
The ability of organophosphate pesticides to disturb immune function has been demonstrated by in vivo and in vitro studies, but evidence of such effects on humans remains scarce. To assess the association between organophosphate pesticides exposure and cytokine levels in Mexican flower workers, a cross-sectional study was carried out. A questionnaire was provided to 121 male flower workers, and urine and blood samples were collected. Using gas chromatography, urinary concentrations of dialkylphosphate metabolites were determined. The serum cytokine levels, IL-4, IL-5, IL-6, IL-8, and IL-10, were measured using multiplex analysis, and levels of INF-γ and TNF-α by ELISA. We found that a higher dialkylphosphate concentration decreased the pro-inflammatory cytokines INF-γ (ß = -0.63; 95â¯% CI -1.22, -0.05), TNF-α (ß= -1.18; 95â¯% CI -2.38, 0.02), and IL-6 (ß= -0.59; 95â¯% CI -1.29, 0.12), and increased IL-10 (ß=0.56; 95â¯% CI 0.02, 1.09), the main anti-inflammatory cytokine, suggesting an imbalance of the immune response in flower workers.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plaguicidas
/
Citocinas
/
Exposición Profesional
Límite:
Adult
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Mexico
Idioma:
En
Revista:
Environ Toxicol Pharmacol
/
Environ. toxicol. pharmacol
/
Environmental toxicology and pharmacology
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Países Bajos