Fabrication and evaluation of nanoemulsion based insulin loaded microneedles for transdermal drug delivery.
Ther Deliv
; 15(8): 605-617, 2024.
Article
en En
| MEDLINE
| ID: mdl-39072401
ABSTRACT
Aim:
Insulin therapy require self-administration of subcutaneous injection leading to painful and inconvenient drug therapy. The aim is to fabricate nanoemulsion (NE) based insulin loaded microneedles with improved bioavailability and patient compliance.Materials &methods:
Different ratios of polyvinyl alcohol and polyvinylpyrrolidone as polymers were prepared through micro-molding technique for microneedles. Characterization of were performed using scanning electron microscope, differential scanning calorimetry, Fourier-transform infrared spectroscopy and circular dichroism. Mechanical strength, hygroscopicity and pain perception of these microneedles were also evaluated. In vitro release, permeation and in vivo PK/PD study of NE-based microneedles were conducted.Results:
NE-based microneedles of insulin have improved bioavailability and quick response.Conclusion:
Microneedles loaded with insulin can be effectively delivered insulin transdermally to treat diabetes with increased convenience and patient compliance.
[Box see text].
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Alcohol Polivinílico
/
Administración Cutánea
/
Emulsiones
/
Hipoglucemiantes
/
Insulina
/
Agujas
Límite:
Animals
Idioma:
En
Revista:
Ther Deliv
Año:
2024
Tipo del documento:
Article
País de afiliación:
Pakistán
Pais de publicación:
Reino Unido