In Vitro and In Silico Evaluation of the Leishmanicidal and Trypanocidal Activities of Lignan Methylpiperitol Isolated from Persea Fulva.
Chem Biodivers
; 21(8): e202400678, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-39086087
ABSTRACT
Neglected Tropical Diseases are a significant concern as they encompass various infections caused by pathogens prevalent in tropical regions. The limited and often highly toxic treatment options for these diseases necessitate the exploration of new therapeutic candidates. In the present study, the lignan methylpiperitol was isolated after several chromatographic steps from Persea fulva L.â
E. Koop (Lauraceae) and its leishmanicidal and trypanocidal activities were evaluated using inâ
vitro and inâ
silico approaches. The chemical structure of methylpiperitol was defined by NMR and MS spectral data analysis. The antiprotozoal activity of methylpiperitol was determined inâ
vitro and indicated potency against trypomastigote forms of Trypanosoma cruzi (EC50 of 4.5±1.1â
mM) and amastigote forms of Leishmania infantum (EC50 of 4.1±0.5â
mM), with no mammalian cytotoxicity against NCTC cells (CC50>200â
mM). Molecular docking studies were conducted using six T. cruzi and four Leishmania. The results indicate that for the molecular target hypoxanthine phosphoribosyl transferase in T. cruzi and piteridine reductase 1 of L. infatum, the methylpiperitol obtained better results than the crystallographic ligand. Therefore, the lignan methylpiperitol, isolated from P. fulva holds potential for the development of new prototypes for the treatment of Neglected Tropical Diseases, especially leishmaniasis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trypanosoma cruzi
/
Lignanos
/
Leishmania infantum
/
Simulación del Acoplamiento Molecular
Límite:
Animals
Idioma:
En
Revista:
Chem Biodivers
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Suiza