Clinical Characteristics, Endoscopic Findings, and Treatment Outcomes in Lymphocytic Esophagitis Compared to Eosinophilic Esophagitis.

ABSTRACT

INTRODUCTION: Lymphocytic and eosinophilic esophagitis (LyE and EoE) are immune-mediated esophageal diseases. Clinical characteristics, endoscopic findings, and treatment outcomes of LyE were compared to EoE. METHODS: This was an international retrospective study on adults enrolled at three centres in Europe. We recorded clinical characteristics and endoscopy findings at baseline, and symptoms, histology, and endoscopy outcomes following treatment of LyE and EoE patients. RESULTS: Demographics, clinical presentation, comorbidities, and endoscopy findings were largely different in 35 LyE compared to 59 EoE. Proton pump inhibitors (PPIs) response was generally lower in LyE. DISCUSSION: LyE is clinically different from EoE, but differences in treatment response need further investigation.