ß-Cell Regeneration Is Driven by Pancreatic Plasticity.
Adv Anat Embryol Cell Biol
; 239: 91-115, 2024.
Article
en En
| MEDLINE
| ID: mdl-39283483
ABSTRACT
The pancreas has been considered a non-regenerative organ. ß cells lost in diabetes are not replaced due to the inability of the pancreas to regenerate. However, ample evidence generated in the last few decades using murine models has demonstrated that the pancreas has a remarkable plasticity wherein differentiated cells can change cell fate toward a ß-like cell phenotype. Although this process is observed after using rather artificial stimuli and the conversion efficiency is very limited, these findings have shed some light on novel pathways for ß-cell regeneration. In this chapter, we will summarize the different cellular interconversion processes described to date, the experimental details and molecular regulation of such interconversions, and the genomic technologies that have allowed the identification of potential new ways to generate ß cells.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Regeneración
/
Células Secretoras de Insulina
/
Plasticidad de la Célula
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Adv Anat Embryol Cell Biol
Año:
2024
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Alemania