Mineralocorticoid receptor antagonist monotherapy in pediatric non-classical 11ß-hydroxylase deficiency.
J Pediatr Endocrinol Metab
; 2024 Sep 20.
Article
en En
| MEDLINE
| ID: mdl-39295130
ABSTRACT
OBJECTIVES:
Congenital adrenal hyperplasia (CAH) is an uncommon genetic disorder which affects cortisol production in the adrenal glands. It is usually treated with glucocorticoids. We present a case of non-classical CAH caused by the partial deficiency of 11 beta-hydroxylase (11ßOH) which was treated with aldosterone antagonist (eplerenone) monotherapy. CASE PRESENTATION An adolescent male was diagnosed with 11 beta-hydroxylase deficiency (11ßOHD) at 13 years of age when he presented with hypertension, fatigue and headaches. He was initially treated with glucocorticoids, but requested an alternative therapy. Eplerenone was commenced at 25â¯mg with subsequent dose increases to 100â¯mg daily. His hypertension was controlled on this regimen, achieving a 24â¯h average blood pressure of 124/81â¯mmHg.CONCLUSIONS:
CAH caused by 11ßOHD is a known cause of hypertension. It is usually managed with glucocorticoids, and antihypertensives are added if blood pressure remains uncontrolled. In this case, glucocorticoid therapy was not tolerated and treatment with aldosterone antagonist monotherapy was effective in controlling his hypertension.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Pediatr Endocrinol Metab
Asunto de la revista:
ENDOCRINOLOGIA
/
PEDIATRIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Irlanda
Pais de publicación:
Alemania