Candidate antibody reference reagents for Chlamydia trachomatis serology.
J Immunol Methods
; 534: 113761, 2024 Sep 24.
Article
en En
| MEDLINE
| ID: mdl-39326782
ABSTRACT
Chlamydia trachomatis (Ct) serology is an important tool for monitoring infection and disease burden but there are currently no formal reference reagents to harmonize results reporting. Our objective was to develop a panel of candidate reference reagents with reactivity against the major outer membrane protein (MOMP) and virulence factor (pgp3) antigens. Plasma packs from females (20-40 years old) were screened against MOMP and pgp3 antigens and selected positive and negative samples pooled to create a panel of candidate antibody reference reagents that were tested in two laboratories. Antigen specificity and internal quality assurance were also evaluated. Suitable candidate materials have been selected to produce Ct reference reagents.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Immunol Methods
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Países Bajos