A Novel Ferrocene-Linked Thionine as a Dual Redox Mediator for the Electrochemical Detection of Dopamine and Hydrogen Peroxide.
Biosensors (Basel)
; 14(9)2024 Sep 19.
Article
en En
| MEDLINE
| ID: mdl-39329823
ABSTRACT
We introduce a novel dual redox mediator synthesized by covalently linking ferrocene dicarboxylic acid (FcDA) and thionine (TH) onto a pre-treated glassy carbon electrode. This unique structure significantly enhances the electro-oxidation of dopamine (DA) and the reduction of hydrogen peroxide (H2O2), offering a sensitive detection method for both analytes. The electrode exhibits exceptional sensitivity, selectivity, and stability, demonstrating potential for practical applications in biosensing. It facilitates rapid electron transfer between the analyte and the electrode surface, detecting H2O2 concentrations ranging from 1.5 to 60 µM with a limit of detection (LoD) of 0.49 µM and DA concentrations from 0.3 to 230 µM with an LoD of 0.07 µM. The electrode's performance was validated through real-sample analyses, yielding satisfactory results.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxidación-Reducción
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Fenotiazinas
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Compuestos Ferrosos
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Técnicas Biosensibles
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Dopamina
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Electrodos
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Técnicas Electroquímicas
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Metalocenos
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Peróxido de Hidrógeno
Idioma:
En
Revista:
Biosensors (Basel)
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Suiza