Novel Iridoid Derivatives Isolated from the Roots of Patrinia scabra with Potential Anti-Renal Fibrosis Activity In Vitro.
Molecules
; 29(18)2024 Sep 17.
Article
en En
| MEDLINE
| ID: mdl-39339414
ABSTRACT
Scabrol B and Scabrol C, two newly identified iridoid derivatives (1 and 2) and six known compounds (3-8), were extracted from the roots of Patrinia scabra. The structures of these derivatives, including their absolute configurations, were elucidated via comprehensive NMR analysis, chemical derivatization, and quantum chemical ECD calculations. All isolated compounds were evaluated for their anti-renal fibrosis activity. The results demonstrate that compounds 1 and 2 showed dose-dependent protective effects against renal fibrosis in vitro by reducing the expression of fibronectin, collagen I, and alpha-smooth muscle actin (α-SMA) in NRK-49f cells mediated by TGF-ß1.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fibrosis
/
Raíces de Plantas
/
Patrinia
/
Iridoides
Límite:
Animals
Idioma:
En
Revista:
Molecules
Asunto de la revista:
BIOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Suiza