Multi-modal risk factors differentiate suicide attempters from ideators in military veterans with major depressive disorder.
J Affect Disord
; 2024 Sep 26.
Article
en En
| MEDLINE
| ID: mdl-39341292
ABSTRACT
BACKGROUND:
The suicide rate for United States military veterans is 1.5× higher than that of non-veterans. To meaningfully advance suicide prevention efforts, research is needed to delineate factors that differentiate veterans with suicide attempt/s, particularly in high-risk groups, e.g., major depressive disorder (MDD), from those with suicidal ideation (no history of attempt/s). The current study aimed to identify clinical, neurocognitive, and neuroimaging variables that differentiate suicide-severity groups in veterans with MDD.METHODS:
Sixty-eight veterans with a DSM-5 diagnosis of MDD, including those with no ideation or suicide attempt (Nâ¯=â¯21; MDD-SI/SA), ideation-only (Nâ¯=â¯17; MDDâ¯+â¯SI), and one-or-more suicide attempts (Nâ¯=â¯30; MDDâ¯+â¯SA; aborted, interrupted, actual attempts), participated in this study. Participants underwent a structured diagnostic interview, neurocognitive assessment, and 3â¯T-structural/diffusion tensor magnetic-resonance-imaging (MRI). Multinomial logistic regression models were conducted to identify variables that differentiated groups with respect to the severity of suicidal behavior.RESULTS:
Relative to veterans with MDD-SI/SA, those with MDDâ¯+â¯SA had significantly higher left cingulum fractional anisotropy, decreased attentional control on emotional-Stroop, and faster response time with intact accuracy on Go/No-Go. Relative to MDDâ¯+â¯SI, MDDâ¯+â¯SA had higher left cingulum fractional anisotropy and faster response time with intact accuracy on Go/No-Go.LIMITATIONS:
Findings are based on retrospective, cross-sectional data and cannot identify causal relationships. Also, a healthy control group was not included given the study's focus on differentiating suicide profiles in MDD.CONCLUSIONS:
This study suggests that MRI and neurocognition differentiate veterans with MDD along the suicide-risk spectrum and could inform suicide-risk stratification and prevention efforts in veterans and other vulnerable populations.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Affect Disord
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Países Bajos