Novel intraprostatic MR-guided implantation of multidrug-eluting microdevice for testing of systemic therapy agents in situ; Proof of concept in intermediate- and high-risk prostate cancer.
J Urol
; : 101097JU0000000000004269, 2024 Sep 30.
Article
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| MEDLINE
| ID: mdl-39348711
ABSTRACT
PURPOSE:
To assess safety and feasibility of percutaneous MR-guided placement of an implantable microdevice (IMD) to evaluate in situ intratumor response to multiple pharmacologic agents in men with intermediate- and high-risk localized prostate cancer. MATERIALS ANDMETHODS:
Biocompatible IMDs measuring 750um in diameter and 5 mm in length were prepared with 20 reservoirs containing candidate drug and drug combinations including second-generation androgen inhibitors, PARP inhibitors, PD-1 inhibitors and conventional chemotherapy. Men with intermediate- or high-risk localized prostate cancer and MRI-visible lesions were enrolled. Up to 4 IMDs were placed via transperineal approach into MRI-visible tumors two days before planned radical prostatectomy. After radical prostatectomy, the IMDs and a small segment of surrounding tumor tissue were removed and sectioned, stained, and analyzed for tissue drug response by a variety of pharmacodynamic markers.RESULTS:
14 patients were enrolled, 7 (50%) with intermediate-risk and 7 (50%) with high-risk localized prostate cancer. A total of 53 IMDs were implanted (mean 3.8 per patient) and 49 (92%) IMDs were successfully retrieved. All men underwent uncomplicated robotic radical prostatectomy and bilateral pelvic lymph node dissection 2 days after IMD placement. There were no severe adverse events. Pathological examination of the tissues adjacent to the IMDs demonstrated differential drug response within patients and between patients. Limitations include small sample size.CONCLUSIONS:
A multi-drug IMD can be safely placed percutaneously into MRI-visible lesions before radical prostatectomy, enabling assessment of tumor-specific local response to multiple agents simultaneously within the tumor's normal stromal environment to guide targeted systemic therapy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Urol
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos