Purified chick embryo cell (PCEC) rabies vaccine for human use. Laboratory data.
Behring Inst Mitt
; (76): 142-54, 1984 Nov.
Article
en En
| MEDLINE
| ID: mdl-6525146
ABSTRACT
A new inactivated rabies vaccine (Purified Chick Embryo Cell vaccine) for use in humans has been developed. The FLURY-LEP C25 strain of rabies virus was adapted to propagate in primary chick embryo cell cultures. The antigen was purified and concentrated by continuous density gradient centrifugation and inactivated by Betapropiolactone. The PCEC-rabies vaccine was tested for innocuity, tolerability and protective capacity in a series of laboratory tests and compared with Human Diploid Cell Strain rabies vaccine (HDCSV) of similar antigenicity. The results of the laboratory tests indicated that this new vaccine was excellently tolerated and that its protective activity met the high standard of HDCS-vaccine, conditions which were imposed on the PCEC-vaccine before clinical trials in man were initiated.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacunas Antirrábicas
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Behring Inst Mitt
Año:
1984
Tipo del documento:
Article