Tissue distribution and deposition of clofazimine in rat following subchronic treatment with or without rifampicin.
Arzneimittelforschung
; 45(9): 1029-31, 1995 Sep.
Article
en En
| MEDLINE
| ID: mdl-7488306
ABSTRACT
Tissue distribution and deposition characteristics of clofazimine (CAS 2030-63-9), an antileprotic drug in rats have been investigated following controlled sub-chronic administration (p.o.) for a period of 1-2 months. The drug was administered alone at a dose of 20 mg/kg body weight and in combination with rifampicin (CAS 13292-46-1) (20 mg/kg p.o.). Various tissues (liver, lung, spleen, small intestine, brain, heart, kidney, skin, stomach and subcutaneous fat) were analyzed for clofazimine in all the treated groups. High levels (range 0.9-3.6 mg/g of wet tissue) were observed in tissues having reticuloendothelial components. In other tissues the levels were relatively lower (range 3-114 micrograms/g of wet tissue). Histopathological studies revealed that clofazimine is deposited in many tissues in the form of reddish-orange crystals. Concomitant treatment with rifampicin did not significantly alter tissue distribution or deposition profile of clofazimine nor did it influence the histopathology.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Rifampin
/
Clofazimina
/
Leprostáticos
Límite:
Animals
Idioma:
En
Revista:
Arzneimittelforschung
Año:
1995
Tipo del documento:
Article
País de afiliación:
India