Hepatotoxicity of antibiotics.
Acta Gastroenterol Belg
; 58(3-4): 290-6, 1995.
Article
en En
| MEDLINE
| ID: mdl-7491842
ABSTRACT
Several antibiotics can cause severe hepatic injury. It is the purpose of this paper to review the main antibiotics that can cause hepatic injury and discuss the presentation, pattern, and outcome of hepatic injury. In the case of the penicillins, the combination amoxycillin-clavulanate and the penicillinase-resistant penicillins oxacillin, (di-)cloxacillin, and flucloxacillin can cause (mainly cholestatic) hepatitis. Cephalosporins have little hepatotoxicity; ceftriaxone can cause drug-induced gallstones. The potential of erythromycin and several other macrolides to cause (usually cholestatic) hepatitis is well established. Tetracyclines can cause a syndrome mimicking acute fatty liver of pregnancy, but this complication has virtually disappeared. Quinolones seem to be able to cause cholestasis. Sulfamethoxazole/trimethoprim can cause severe hepatotoxicity, especially in patients with acquired immunodeficiency syndrome (AIDS). Finally, nitrofurantoin can cause acute cholestatic and hepatocellular reactions as well as chronic hepatitis mimicking chronic auto-immune hepatitis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Hígado
/
Antibacterianos
Límite:
Adult
/
Child
/
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
En
Revista:
Acta Gastroenterol Belg
Año:
1995
Tipo del documento:
Article
País de afiliación:
Bélgica