Pathogenicity, attenuation, and immunogenicity of infectious bursal disease virus.
Avian Dis
; 40(3): 567-71, 1996.
Article
en En
| MEDLINE
| ID: mdl-8883785
ABSTRACT
An investigation was conducted in specific-pathogen-free chickens on the pathogenicity of bursa-derived and tissue culture-attenuated classic (STC) and variant (IN) serotype 1 strains of infectious bursal disease virus. The IN bursa-derived virus caused bursal inflammation, necrosis, and atrophy earlier than the bursa-derived STC virus. Both viruses lost their pathogenicity after four passages in BGM-70 cells. A statistically significant level (P < 0.05) of protection was observed in SPF chickens vaccinated with the attenuated IN virus used as a live or inactivated vaccine followed by homologous (IN) and heterologous (STC) challenge with bursa-derived viruses.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virus de la Enfermedad Infecciosa de la Bolsa
Límite:
Animals
Idioma:
En
Revista:
Avian Dis
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos