Platelet adhesion to novel phospholipid materials: modified phosphatidylcholine covalently immobilized to silica, polypropylene, and PTFE materials.
J Biomed Mater Res
; 32(2): 237-42, 1996 Oct.
Article
en En
| MEDLINE
| ID: mdl-8884501
ABSTRACT
Based on the premise of achieving blood compatibility through mimicking the chemical constitutents of the biologically insert surface of the unactivated platelet membrane, a process was developed that entails the covalent grafting of modified phosphatidylcholine molecules to materials including silica, polypropylene, and polytetrafluoroethylene (PTFE) polymer films. These materials were characterized using x-ray photoelectron spectroscopy (XPS) and contactangle measurements. The phosphatidylcholine-containing materials (PC materials) were used as substrates in the plateletadhesion assays and were subjected to enzymatic degradation evaluation. Phosphatidylcholine-grafted silica materials do not support platelet adhesion. In addition the number of adherent platelets correlate with the amount of grafted phospholipid present, as indicated by the phosphorus/ carbon ratio obtained by XPS analysis. Platelet adhesion to phosphatidylcholine-grafted polypropylene and PTFE was inhibited 80% and 90%, respectively, when compared with platelet adhesion to unmodified polypropylene and PTFE.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfatidilcolinas
/
Polipropilenos
/
Politetrafluoroetileno
/
Materiales Biocompatibles
/
Plaquetas
/
Adhesividad Plaquetaria
/
Dióxido de Silicio
Límite:
Humans
Idioma:
En
Revista:
J Biomed Mater Res
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos