Model of in vitro granulomatous hypersensitivity in human paracoccidioidomycosis.
Mycopathologia
; 137(3): 129-36, 1997.
Article
en En
| MEDLINE
| ID: mdl-9368406
With the purpose of studying the immunological components of granulomatous hypersensitivity in patients infected with Paracoccidioides brasiliensis, we used the model of in vitro granuloma formation developed for schistosomiasis studies, that correlates with in vivo granulomatous reactivity occurring around eggs trapped in organs of infected donors. In this case, granuloma formation can be determined examining cellular reactivity manifested as multiple cell layers surrounding antigen-conjugated polyacrilamide beads. Our results showed that peripheral blood mononuclear cells (PBMC) obtained from acute treated and chronic paracoccidioidomycosis patients proliferate and generate in vitro granulomas in response to P. brasiliensis antigens (PbAg). In contrast, no proliferation or granuloma formation were observed when PBMC from acute non-treated patients were used. These studies demonstrate the feasibility of investigating granulomatous hypersensitivity in P. brasiliensis-infected patients by using an in vitro granuloma model.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Paracoccidioidomicosis
/
Granuloma
/
Modelos Biológicos
Límite:
Adult
/
Child
/
Humans
/
Middle aged
Idioma:
En
Revista:
Mycopathologia
Año:
1997
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Países Bajos