Congenital abnormalities in Brazilian children associated with misoprostol misuse in first trimester of pregnancy.
Lancet
; 351(9116): 1624-7, 1998 May 30.
Article
en En
| MEDLINE
| ID: mdl-9620717
ABSTRACT
PIP: In Brazil and other South and Central American countries where abortion is illegal, misoprostol is widely available and commonly used to induce abortion. However, misoprostol is not very effective as an abortifacient agent and can cause fetal abnormalities. The present study reviewed the cases of 42 infants from Sao Paulo, Brazil, who were exposed to misoprostol during the first trimester of pregnancy and then born with a congenital abnormality. 17 children had equinovarus with cranial nerve deficiencies and 10 had equinovarus as part of a more extensive arthrogryposis. The most distinctive phenotypes were arthrogryposis confined to the legs (5 cases) and terminal transverse limb defects (9 cases). Congenital hydrocephalus was present in 8 children. The most commonly taken dose of misoprostol was 800 mcg (range, 200-16,000 mcg). Greater awareness of the widespread use of misoprostol to induce abortion should lead to public health interventions to prevent teratogenic effects.
Palabras clave
Abortifacient Agents--side effects; Abortion Failure; Abortion, Drug Induced; Abortion, Induced; Americas; Biology; Brazil; Case Studies; Congenital Abnormalities; Developing Countries; Diseases; Endocrine System; Family Planning; Fertility Control, Postconception; Fetus; Latin America; Misoprostol--side effects; Neonatal Diseases And Abnormalities; Physiology; Pregnancy; Pregnancy, First Trimester; Prostaglandins; Prostaglandins, Synthetic; Reproduction; Research Methodology; Research Report; South America; Studies
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Artrogriposis
/
Anomalías Inducidas por Medicamentos
/
Abortivos no Esteroideos
/
Pie Equinovaro
/
Aborto Criminal
/
Misoprostol
/
Nervios Craneales
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Lancet
Año:
1998
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Reino Unido