Novel thiazolidinedione derivatives with retinoid synergistic activity.

Ebisawa, M; Kawachi, E; Fukasawa, H; Hashimoto, Y; Itai, A; Shudo, K; Kagechika, H

Ebisawa, M; Kawachi, E; Fukasawa, H; Hashimoto, Y; Itai, A; Shudo, K; Kagechika, H.

Afiliación

Ebisawa M; Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.

Biol Pharm Bull ; 21(5): 547-9, 1998 May.

Article en En | MEDLINE | ID: mdl-9635519

RESUMEN

Several arylmethylidene thiazolidinediones were synthesized and their retinoidal activities were examined. TZ181 (7a), having a benzanilide skeleton, exhibited differentiation-inducing activity in HL-60 cell assay, while TZ191 (7b), the N-methylated analog of TZ181 (7a), TZ245 (9) and TZ335 (10) acted as retinoid synergists like the RXR-selective ligand, LGD1069 (5).

Asunto(s)

Retinoides/farmacología; Tiazoles/farmacología; Diferenciación Celular/efectos de los fármacos; Sinergismo Farmacológico; Células HL-60; Humanos; Relación Estructura-Actividad

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Retinoides / Tiazoles Límite: Humans Idioma: En Revista: Biol Pharm Bull Asunto de la revista: BIOQUIMICA / FARMACOLOGIA Año: 1998 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón

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