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Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells: Nafamostat is the most potent antiviral drug candidate
Meehyun Ko; Sangeun Jeon; Wang-Shick Ryu; Seungtaek Kim.
Afiliación
  • Meehyun Ko; Institut Pasteur Korea
  • Sangeun Jeon; Institut Pasteur Korea
  • Wang-Shick Ryu; Institut Pasteur Korea
  • Seungtaek Kim; Institut Pasteur Korea
Preprint en Inglés | bioRxiv | ID: ppbiorxiv-090035
ABSTRACT
Drug repositioning represents an effective way to control the current COVID-19 pandemic. Previously, we identified 24 FDA-approved drugs which exhibited substantial antiviral effect against SARS-CoV-2 in Vero cells. Since antiviral efficacy could be altered in different cell lines, we developed an antiviral screening assay with human lung cells, which is more appropriate than Vero cell. Comparative analysis of antiviral activities revealed that nafamostat is the most potent drug in human lung cells (IC50 = 0.0022{micro}M).
Licencia
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Texto completo: Disponible Colección: Preprints Base de datos: bioRxiv Idioma: Inglés Año: 2020 Tipo del documento: Preprint
Texto completo: Disponible Colección: Preprints Base de datos: bioRxiv Idioma: Inglés Año: 2020 Tipo del documento: Preprint
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