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Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19
Simon P Graham; Rebecca K McLean; Alexandra J Spencer; Sandra Belij-Rammerstorfer; Daniel Wright; Marta Ulaszewska; Jane C Edwards; Jack W P Hayes; Veronica Martini; Nazia Thakur; Carina Conceicao; Isabelle Dietrich; Holly Shelton; Ryan Waters; Anna Ludi; Ginette Wilsden; Clare Browning; Dagmara Bialy; Sushant Bhat; Phoebe Stevenson-Leggett; Philippa Hollinghurst; Ciaran Gilbride; David Pulido; Katy Moffat; Hannah Sharpe; Elizabeth Allen; Valerie Mioulet; Chris Chiu; Joseph Newman; Amin S Asfor; Alison Burman; Sylvia Crossley; Jiandong Huo; Raymond J Owens; Miles Carroll; John A Hammond; Elma Tchilian; Dalan Bailey; Bryan Charleston; Sarah C Gilbert; Tobias J Tuthill; Teresa Lambe.
Afiliación
  • Simon P Graham; The Pirbright Institute
  • Rebecca K McLean; The Pirbright Institute
  • Alexandra J Spencer; University of Oxford
  • Sandra Belij-Rammerstorfer; University of Oxford
  • Daniel Wright; University of Oxford
  • Marta Ulaszewska; University of Oxford
  • Jane C Edwards; The Pirbright Institute
  • Jack W P Hayes; The Pirbright Institute
  • Veronica Martini; The Pirbright Institute
  • Nazia Thakur; The Pirbright Institute
  • Carina Conceicao; The Pirbright Institute
  • Isabelle Dietrich; The Pirbright Institute
  • Holly Shelton; The Pirbright institute
  • Ryan Waters; The Pirbright Institute
  • Anna Ludi; The Pirbright Institute
  • Ginette Wilsden; The Pirbright Institute
  • Clare Browning; The Pirbright Institute
  • Dagmara Bialy; The Pirbright Institute
  • Sushant Bhat; The Pirbright Institute
  • Phoebe Stevenson-Leggett; The Pirbright Institute
  • Philippa Hollinghurst; The Pirbright Institute
  • Ciaran Gilbride; University of Oxford
  • David Pulido; University of Oxford
  • Katy Moffat; The Pirbright Institute
  • Hannah Sharpe; University of Oxford
  • Elizabeth Allen; University of Oxford
  • Valerie Mioulet; The Pirbright Institute
  • Chris Chiu; The Pirbright Institute
  • Joseph Newman; The Pirbright Institute
  • Amin S Asfor; The Pirbright Institute
  • Alison Burman; The Pirbright Institute
  • Sylvia Crossley; The Pirbright Institute
  • Jiandong Huo; University of Oxford
  • Raymond J Owens; University of Oxford
  • Miles Carroll; Public Health England
  • John A Hammond; The Pirbright Institute
  • Elma Tchilian; The Pirbright Institute
  • Dalan Bailey; The Pirbright Institute
  • Bryan Charleston; The Pirbright Institute
  • Sarah C Gilbert; University of Oxford
  • Tobias J Tuthill; The Pirbright Institute
  • Teresa Lambe; University of Oxford
Preprint en Inglés | bioRxiv | ID: ppbiorxiv-159715
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ABSTRACT
Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. Here, we compared the immunogenicity of one or two doses of ChAdOx1 nCoV-19 in both mice and pigs. Whilst a single dose induced antigen-specific antibody and T cells responses, a booster immunisation enhanced antibody responses, particularly in pigs, with a significant increase in SARS-CoV-2 neutralising titres.
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Texto completo: Disponible Colección: Preprints Base de datos: bioRxiv Tipo de estudio: Experimental_studies / Estudio pronóstico Idioma: Inglés Año: 2020 Tipo del documento: Preprint
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: Disponible Colección: Preprints Base de datos: bioRxiv Tipo de estudio: Experimental_studies / Estudio pronóstico Idioma: Inglés Año: 2020 Tipo del documento: Preprint