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An Antioxidant Enzyme Therapeutic for COVID-19
Meng Qin; Zheng Cao; Jing Wen; Qingsong Yu; Chaoyong Liu; Fang Wang; Fengmei Yang; Yanyan Li; Gregory A. Fishbein; Sen Yan; Bin Xu; Yi Hou; Zhenbo Ning; Kaili Nie; Ni Jiang; Zhen Liu; Jun Wu; Yanting Yu; Heng Li; Huiwen Zheng; Jing Li; Weihua Jin; Sheng Pan; Shuai Wang; Jianfeng Chen; Zhihua Gan; Zhanlong He; Yunfeng Lu.
Afiliación
  • Meng Qin; Beijing University of Chemical Technology
  • Zheng Cao; University of California, Los Angeles
  • Jing Wen; University of California, Los Angeles
  • Qingsong Yu; Beijing University of Chemical Technology
  • Chaoyong Liu; Beijing University of Chemical Technology
  • Fang Wang; Beijing University of Chemical Technology
  • Fengmei Yang; Institute of Medical Biology, Chinese Academy of Medical Sciences
  • Yanyan Li; Institute of Medical Biology, Chinese Academy of Medical Sciences
  • Gregory A. Fishbein; University of California, Los Angeles
  • Sen Yan; Jinan University
  • Bin Xu; University of California, Los Angeles
  • Yi Hou; Beijing University of Chemical Technology
  • Zhenbo Ning; Beijing University of Chemical Technology
  • Kaili Nie; Beijing University of Chemical Technology
  • Ni Jiang; Beijing University of Chemical Technology
  • Zhen Liu; Beijing University of Chemical Technology
  • Jun Wu; Beijing University of Chemical Technology
  • Yanting Yu; Beijing University of Chemical Technology
  • Heng Li; Institute of Medical Biology, Chinese Academy of Medical Sciences
  • Huiwen Zheng; Institute of Medical Biology, Chinese Academy of Medical Sciences
  • Jing Li; Institute of Medical Biology, Chinese Academy of Medical Sciences
  • Weihua Jin; Institute of Medical Biology, Chinese Academy of Medical Sciences
  • Sheng Pan; Vivibaba, Inc.
  • Shuai Wang; Vivibaba Inc.
  • Jianfeng Chen; Beijing University of Chemical Technology
  • Zhihua Gan; Beijing University of Chemical Technology
  • Zhanlong He; Institute of Medical Biology, Chinese Academy of Medical Sciences,
  • Yunfeng Lu; University of California, Los Angeles
Preprint en En | PREPRINT-BIORXIV | ID: ppbiorxiv-205211
Artículo de revista
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ABSTRACT
The COVID-19 pandemic has taken a significant toll on people worldwide, and there are currently no specific antivirus drugs or vaccines. We report herein a therapeutic based on catalase, an antioxidant enzyme that can effectively breakdown hydrogen peroxide and minimize the downstream reactive oxygen species, which are excessively produced resulting from the infection and inflammatory process. Catalase assists to regulate production of cytokines, protect oxidative injury, and repress replication of SARS-CoV-2, as demonstrated in human leukocytes and alveolar epithelial cells, and rhesus macaques, without noticeable toxicity. Such a therapeutic can be readily manufactured at low cost as a potential treatment for COVID-19.
Licencia
cc_by_nc
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-BIORXIV Idioma: En Año: 2020 Tipo del documento: Preprint
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-BIORXIV Idioma: En Año: 2020 Tipo del documento: Preprint