The phenotypic changes of γδ T cells in COVID-19 patients

Lei Lei; Hongbo Qian; Xiaofeng Yang; Xiaobo Zhou; Xingzhe Zhang; Dan Zhang; Tongxin Dai; Rui Guo; Lin Shi; Yanbin Cheng; Baojun Zhang; Jinsong Hu Hu; Yaling Guo

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The phenotypic changes of γδ T cells in COVID-19 patients

Lei Lei; Hongbo Qian; Xiaofeng Yang; Xiaobo Zhou; Xingzhe Zhang; Dan Zhang; Tongxin Dai; Rui Guo; Lin Shi; Yanbin Cheng; Baojun Zhang; Jinsong Hu Hu; Yaling Guo.

Afiliación

Lei Lei; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center
Hongbo Qian; Department of Clinical Laboratory, The 8th hospital of Xi'an
Xiaofeng Yang; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center
Xiaobo Zhou; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center
Xingzhe Zhang; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center
Dan Zhang; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center
Tongxin Dai; Department of Clinical Laboratory, The 8th hospital of Xi'an
Rui Guo; Department of Clinical Laboratory, The 8th hospital of Xi'an
Lin Shi; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center
Yanbin Cheng; Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center
Baojun Zhang; Xi'an Jiaotong University
Jinsong Hu Hu; Xi'an Jiaotong University
Yaling Guo; Department of Clinical Laboratory, The 8th hospital of Xi'an

Preprint en En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20046433

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ABSTRACT

ABSTRACT

A novel pneumonia-associated respiratory syndrome named coronavirus disease-2019 (COVID-19), which caused by SARS-CoV-2 and broken in Wuhan, China in the end of 2019. Unfortunately, there is no specific antiviral agent or vaccine available to treat SARS-CoV-2 infections. Also, information regarding the immunological characteristics in COVID-19 patients remains limited. Here we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes in {gamma}{delta} T cells. In comparison to HD, the {gamma}{delta} T cells percentage was decreased. {gamma}{delta} T cells are able to immediately respond to SARS-CoV-2 infection and upregulate the activation marker CD25. In addition, the increased expression of CD4 in {gamma}{delta} T cells may serve as a biomarker for the assessment of SARS-CoV-2 infection.

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Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Idioma: En Año: 2020 Tipo del documento: Preprint

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Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Idioma: En Año: 2020 Tipo del documento: Preprint