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Viral genome sequencing places White House COVID-19 outbreak into phylogenetic context
Trevor Bedford; Jennifer K. Logue; Peter D. Han; Caitlin R. Wolf; Chris D. Frazar; Benjamin Pelle; Erica Ryke; James Hadfield; Jover Lee; Mark J Rieder; Deborah A. Nickerson; Christina M. Lockwood; Lea M. Starita; Helen Y. Chu; Jay Shendure.
Afiliación
  • Trevor Bedford; Fred Hutchinson Cancer Research Center
  • Jennifer K. Logue; University of Washington
  • Peter D. Han; University of Washington
  • Caitlin R. Wolf; University of Washington
  • Chris D. Frazar; University of Washington
  • Benjamin Pelle; University of Washington
  • Erica Ryke; University of Washington
  • James Hadfield; Fred Hutchinson Cancer Research Center
  • Jover Lee; Fred Hutchinson Cancer Research Center
  • Mark J Rieder; University of Washington
  • Deborah A. Nickerson; University of Washington
  • Christina M. Lockwood; University of Washington
  • Lea M. Starita; University of Washington
  • Helen Y. Chu; University of Washington
  • Jay Shendure; University of Washington
Preprint en Inglés | medRxiv | ID: ppmedrxiv-20223925
ABSTRACT
In October 2020, an outbreak of at least 50 COVID-19 cases was reported surrounding individuals employed at or visiting the White House. Here, we applied genomic epidemiology to investigate the origins of this outbreak. We enrolled two individuals with exposures linked to the White House COVID-19 outbreak into an IRB-approved research study and sequenced their SARS-CoV-2 infections. We find these viral sequences are identical to each other, but are distinct from over 190,000 publicly available SARS-CoV-2 genomes. These genomes fall as part of a lineage circulating in the USA since April or May 2020 and detected in Virginia and Michigan. Looking forwards, sequencing of additional community SARS-CoV-2 infections collected in the USA prior to October 2020 may shed further light on its geographic ancestry. In sequencing of SARS-CoV-2 infections collected after October 2020, it may be possible to identify infections that likely descend from the White House COVID-19 outbreak.
Licencia
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Texto completo: Disponible Colección: Preprints Base de datos: medRxiv Idioma: Inglés Año: 2020 Tipo del documento: Preprint
Texto completo: Disponible Colección: Preprints Base de datos: medRxiv Idioma: Inglés Año: 2020 Tipo del documento: Preprint
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