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Durability of SARS-CoV-2-specific IgG responses in saliva for up to 8 months after infection
Pranay R. Randad; Nora Pisanic; Kate Kruczynski; Tyrone Howard; Magdielis Gregory Rivera; Kristoffer Spicer; Annukka A.R. Antar; Tristan Penson; David L. Thomas; Andrew Pekosz; Nelson Ndahiro; Lateef Aliyu; Michael J. Betenbaugh; Hannah Manley; Barbara Detrick; Morgan Katz; Sara Cosgrove; Claire Rock; Israel Zyskind; Jonathan I. Silverberg; Avi Z. Rosenberg; Priya Duggal; Yukari C. Manabe; Matthew H. Collins; Christopher D. Heaney.
Afiliación
  • Pranay R. Randad; Johns Hopkins Bloomberg School of Public Health
  • Nora Pisanic; Johns Hopkins Bloomberg School of Public Health
  • Kate Kruczynski; Johns Hopkins Bloomberg School of Public Health
  • Tyrone Howard; Johns Hopkins Bloomberg School of Public Health
  • Magdielis Gregory Rivera; Johns Hopkins Bloomberg School of Public Health
  • Kristoffer Spicer; Johns Hopkins Bloomberg School of Public Health
  • Annukka A.R. Antar; Johns Hopkins University School of Medicine
  • Tristan Penson; Johns Hopkins University School of Medicine
  • David L. Thomas; Johns Hopkins University School of Medicine
  • Andrew Pekosz; Johns Hopkins Bloomberg School of Public Health
  • Nelson Ndahiro; Johns Hopkins University Whiting School of Engineering
  • Lateef Aliyu; Johns Hopkins University Whiting School of Engineering
  • Michael J. Betenbaugh; Johns Hopkins University Whiting School of Engineering
  • Hannah Manley; Johns Hopkins Bloomberg School of Public Health
  • Barbara Detrick; Johns Hopkins University School of Medicine
  • Morgan Katz; Johns Hopkins University School of Medicine
  • Sara Cosgrove; Johns Hopkins University School of Medicine
  • Claire Rock; Johns Hopkins University School of Medicine
  • Israel Zyskind; NYU Langone
  • Jonathan I. Silverberg; George Washington University School of Medicine and Health Sciences
  • Avi Z. Rosenberg; Johns Hopkins University School of Medicine
  • Priya Duggal; Johns Hopkins Bloomberg School of Public Health
  • Yukari C. Manabe; Johns Hopkins University School of Medicine
  • Matthew H. Collins; Emory University School of Medicine
  • Christopher D. Heaney; Johns Hopkins Bloomberg School of Public Health
Preprint en En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21252149
ABSTRACT
We evaluated the durability of IgG responses specific to SARS-CoV-2 nucleocapsid (N), receptor binding domain (RBD), and spike (S) antigens in saliva up to 8 months after RT-PCR-confirmed COVID-19 using a multiplex salivary assay. We estimated a half-life of 64 days (d) (95% CI 49, 80 d) for N, 100 d for RBD (95% CI 58, 141 d), and 148 d (95% CI 62, 238 d) for S IgG responses in saliva, consistent with half-life estimates previously reported in blood. Saliva can serve as an alternative to blood to monitor humoral immune responses on a large scale following SARS-CoV-2 infection and vaccination for surveillance and assessment of population immunity.
Licencia
cc_by_nc_nd
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Experimental_studies Idioma: En Año: 2021 Tipo del documento: Preprint
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Experimental_studies Idioma: En Año: 2021 Tipo del documento: Preprint