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Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - a high risk community-hospital interface
Y. Mun Woo; Oliver Stirrup; Kathy Li; Joseph Hughes; Antonia Ho; Ana Da Silva Filipe; Natasha Johnson; Katherine Smollett; Daniel Mair; Stephen Carmichael; Lily Tong; Jenna Nichols; Elihu Aranday-Cortes; Kirstyn Brunker; Yasmin A. Parr; Kyriaki Nomikou; Sarah E McDonald; Marc Niebel; Patawee Asamaphan; Vattipally B Sreenu; David L Robertson; Aislynn Taggart; Natasha Jesudason; Rajiv Shah; James G Shepherd; Josh Singer; Alison HM Taylor; Zoe Cousland; Jonathan Price; Jennifer Lees; Timothy P.W. PW Jones; Carlos Varon Lopez; Alasdair MacLean; Igor Starinskij; Rory Gunson; Scott T.W. Morris; Peter C. Thomson; Colin C Geddes; Jamie P. Traynor; Judith G Breuer; - The COVID-19 Genomics UK (COG-UK) consortium; Emma C Thomson; Patrick B Mark.
Afiliación
  • Y. Mun Woo; The Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital University Hospital, 1345 Govan Road, Glasgow, G51 4TF, UK
  • Oliver Stirrup; University College London
  • Kathy Li; University of Glasgow
  • Joseph Hughes; MRC-University of Glasgow
  • Antonia Ho; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Ana Da Silva Filipe; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Natasha Johnson; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Katherine Smollett; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Daniel Mair; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Stephen Carmichael; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Lily Tong; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Jenna Nichols; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Elihu Aranday-Cortes; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Kirstyn Brunker; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Yasmin A. Parr; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Kyriaki Nomikou; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Sarah E McDonald; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Marc Niebel; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Patawee Asamaphan; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Vattipally B Sreenu; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • David L Robertson; University of Glasgow
  • Aislynn Taggart; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Natasha Jesudason; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Rajiv Shah; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • James G Shepherd; University of Glasgow
  • Josh Singer; MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker building, 464 Bearsden Road, Glasgow, G61 1QH
  • Alison HM Taylor; Renal Unit, University Hospital Monklands, Monkscourt Ave, Airdrie ML6 0JS
  • Zoe Cousland; Renal Unit, University Hospital Monklands, Monkscourt Ave, Airdrie ML6 0JS
  • Jonathan Price; Renal Unit, University Hospital Monklands, Monkscourt Ave, Airdrie ML6 0JS
  • Jennifer Lees; Renal Unit, University Hospital Monklands, Monkscourt Ave, Airdrie ML6 0JS
  • Timothy P.W. PW Jones; Department of Infectious Diseases, University Hospital Monklands, Monkscourt Ave, Airdrie ML60JS
  • Carlos Varon Lopez; Department of Microbiology, University Hospital Monklands, Monkscourt Ave, Airdrie ML6 0JS
  • Alasdair MacLean; West of Scotland Specialist Virology Centre, Glasgow Royal Infirmary
  • Igor Starinskij; West of Scotland Specialist Virology Centre, Glasgow Royal Infirmary
  • Rory Gunson; West of Scotland Specialist Virology Centre, Glasgow Royal Infirmary
  • Scott T.W. Morris; The Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital University Hospital, 1345 Govan Road, Glasgow, G51 4TF, UK
  • Peter C. Thomson; The Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital University Hospital, 1345 Govan Road, Glasgow, G51 4TF, UK
  • Colin C Geddes; The Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital University Hospital, 1345 Govan Road, Glasgow, G51 4TF, UK
  • Jamie P. Traynor; The Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital University Hospital, 1345 Govan Road, Glasgow, G51 4TF, UK
  • Judith G Breuer; University College London
  • - The COVID-19 Genomics UK (COG-UK) consortium;
  • Emma C Thomson; University of Glasgow
  • Patrick B Mark; The Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital University Hospital, 1345 Govan Road, Glasgow, G51 4TF, UK
Preprint en Inglés | medRxiv | ID: ppmedrxiv-21253587
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ABSTRACT
ObjectivesPatients requiring haemodialysis are at increased risk of serious illness with SARS-CoV-2 infection. To improve the understanding of transmission risks in six Scottish renal dialysis units, we utilised the rapid whole-genome sequencing data generated by the COG-UK consortium. MethodsWe combined geographical, temporal and genomic sequence data from the community and hospital to estimate the probability of infection originating from within the dialysis unit, the hospital or the community using Bayesian statistical modelling and compared these results to the details of epidemiological investigations. ResultsOf 671 patients, 60 (8.9%) became infected with SARS-CoV-2, of whom 16 (27%) died. Within-unit and community transmission were both evident and an instance of transmission from the wider hospital setting was also demonstrated. ConclusionsNear-real-time SARS-CoV-2 sequencing data can facilitate tailored infection prevention and control measures, which can be targeted at reducing risk in these settings.
Licencia
cc_by_nc_nd
Texto completo: Disponible Colección: Preprints Base de datos: medRxiv Tipo de estudio: Estudio observacional / Estudio pronóstico Idioma: Inglés Año: 2021 Tipo del documento: Preprint
Texto completo: Disponible Colección: Preprints Base de datos: medRxiv Tipo de estudio: Estudio observacional / Estudio pronóstico Idioma: Inglés Año: 2021 Tipo del documento: Preprint
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