Your browser doesn't support javascript.
loading
Non-severe SARS-CoV-2 infection is characterised by very early T cell proliferation independent of type 1 interferon responses and distinct from other acute respiratory viruses.
Aneesh Chandran; Joshua Rosenheim; Gayathrie Nageswaran; Leo Swadling; Gabriele Pollara; Rishi Gupta; Jose Afonso Guerra-Assuncao; Annemarie Woolston; Tahel Ronel; Corrina Pade; Joseph Gibbons; Blanca Sanz-Magallon Duque De Estrada; Marc Robert de Massy; Matthew Whelan; Amanda Semper; Tim Brooks; Daniel M Altmann; Rosemary J Boyton; Aine McKnight; Charlotte Manisty; Thomas Alexander Treibel; James Moon; Gillian S Tomlinson; Mala K Maini; Benjamin M Chain; Mahdad Noursadeghi; - COVIDsortium investigators.
Afiliación
  • Aneesh Chandran; Division of Infection and Immunity, University College London, London, UK
  • Joshua Rosenheim; Division of Infection and Immunity, University College London, London, UK
  • Gayathrie Nageswaran; Division of Infection and Immunity, University College London, London, UK
  • Leo Swadling; Division of Infection and Immunity, University College London, London, UK
  • Gabriele Pollara; Division of Infection and Immunity, University College London, London, UK
  • Rishi Gupta; Institute of Global Health, University College London, London, UK
  • Jose Afonso Guerra-Assuncao; Division of Infection and Immunity, University College London, London, UK
  • Annemarie Woolston; Division of Infection and Immunity, University College London, London, UK
  • Tahel Ronel; Division of Infection and Immunity, University College London, London, UK
  • Corrina Pade; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Joseph Gibbons; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Blanca Sanz-Magallon Duque De Estrada; Division of Infection and Immunity, University College London, London, UK
  • Marc Robert de Massy; Division of Infection and Immunity, University College London, London, UK
  • Matthew Whelan; Division of Infection and Immunity, University College London, London, UK
  • Amanda Semper; National Infection Service, Public Health England, Porton Down, UK
  • Tim Brooks; National Infection Service, Public Health England, Porton Down, UK
  • Daniel M Altmann; Department of Immunology and Inflammation, Imperial College London, London, UK
  • Rosemary J Boyton; Lung Division, Royal Brompton & Harefield NHS Foundation Trust, London, UK
  • Aine McKnight; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  • Charlotte Manisty; Institute of Cardiovascular Sciences, University College London, London, UK
  • Thomas Alexander Treibel; Institute of Cardiovascular Sciences, University College London, London, UK
  • James Moon; Institute of Cardiovascular Sciences, University College London, London, UK
  • Gillian S Tomlinson; Division of Infection and Immunity, University College London, London, UK
  • Mala K Maini; Division of Infection and Immunity, University College London, London, UK
  • Benjamin M Chain; Division of Infection and Immunity, University College London, London, UK
  • Mahdad Noursadeghi; Division of Infection and Immunity, University College London, London, UK
  • - COVIDsortium investigators;
Preprint en Inglés | medRxiv | ID: ppmedrxiv-21254540
ABSTRACT
The correlates of natural protective immunity to SARS-CoV-2 in the majority who experience asymptomatic infection or non-severe disease are not fully characterised, and remain important as new variants emerge. We addressed this question using blood transcriptomics, multiparameter flow cytometry and T cell receptor (TCR) sequencing spanning the time of incident infection. We identified a type 1 interferon (IFN) response common to other acute respiratory viruses, and a cell proliferation response that discriminated SARS-CoV-2 from other viruses. These responses peaked by the time the virus was first detected, and in some preceded virus detection. Cell proliferation was most evident in CD8 T cells and associated with rapid expansion of SARS-CoV-2 reactive TCRs. We found an equally rapid increase in immunoglobulin transcripts, but circulating virus-specific antibodies lagged by 1-2 weeks. Our data support a protective role for rapid induction of type 1 IFN and CD8 T cell responses to SARS-CoV-2.
Licencia
cc_by_nc_nd
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: Disponible Colección: Preprints Base de datos: medRxiv Idioma: Inglés Año: 2021 Tipo del documento: Preprint
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: Disponible Colección: Preprints Base de datos: medRxiv Idioma: Inglés Año: 2021 Tipo del documento: Preprint