Este articulo es un Preprint
Los preprints son informes de investigación preliminares que no han sido certificados por revisión por pares. No deben considerarse para guiar la práctica clínica o los comportamientos relacionados con la salud y no deben publicarse en los medios como información establecida.
Los preprints publicados en línea permiten a los autores recibir comentarios rápidamente, y toda la comunidad científica puede evaluar de forma independiente el trabajo y responder adecuadamente. Estos comentarios se publican junto con los preprints para que cualquiera pueda leer y servir como una revisión pospublicación.
The SARS-CoV-2 Alpha variant is associated with increased clinical severity of disease
Preprint
en Inglés
| medRxiv
| ID: ppmedrxiv-21260128
ABSTRACT
ObjectivesThe SARS-CoV-2 Alpha variant was associated with increased transmission relative to other variants present at the time of its emergence and several studies have shown an association between Alpha variant infection and increased hospitalisation and 28-day mortality. However, none have addressed the impact on maximum severity of illness in the general population classified by the level of respiratory support required, or death. We aimed to do this. MethodsIn this retrospective multi-centre clinical cohort sub-study of the COG-UK consortium, 1475 samples from Scottish hospitalised and community cases collected between 1st November 2020 and 30th January 2021 were sequenced. We matched sequence data to clinical outcomes as the variant became dominant in Scotland and modelled the association between Alpha variant infection and severe disease using a 4-point scale of maximum severity by 28 days 1. no respiratory support, 2. supplemental oxygen, 3. ventilation and 4. death. ResultsOur cumulative generalised linear mixed model analyses found evidence (cumulative odds ratio 1.40, 95% CI 1.02, 1.93) of a positive association between increased clinical severity and lineage (Alpha variant versus non-Alpha variant). ConclusionsThe Alpha variant was associated with more severe clinical disease in the Scottish population than co-circulating lineages.
cc_by
Texto completo:
Disponible
Colección:
Preprints
Base de datos:
medRxiv
Tipo de estudio:
Cohort_studies
/
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Año:
2021
Tipo del documento:
Preprint