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Exposures to different SARS-CoV-2 spike variants elicit neutralizing antibody responses with differential specificity towards established and emerging strains
Matthew T Laurie; Jamin Liu; Sara Sunshine; James Peng; Douglas Black; Anthea M Mitchell; Sabrina A Mann; Genay Pilarowski; Kelsey C Zorn; Luis Rubio; Sara Bravo; Joseph J Sabatino; Kristen Mittl; Carina Marquez; Maya Petersen; Diane Havlir; Joseph DeRisi.
Afiliación
  • Matthew T Laurie; Department of Biochemistry and Biophysics, University of California San Francisco, CA 94143, USA
  • Jamin Liu; Department of Biochemistry and Biophysics, University of California San Francisco, CA 94143, USA; University of California, Berkeley-University of California, S
  • Sara Sunshine; Department of Biochemistry and Biophysics, University of California San Francisco, CA 94143, USA
  • James Peng; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
  • Douglas Black; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
  • Anthea M Mitchell; Department of Biochemistry and Biophysics, University of California San Francisco, CA 94143, USA
  • Sabrina A Mann; Department of Biochemistry and Biophysics, University of California San Francisco, CA 94143, USA
  • Genay Pilarowski; Department of Biochemistry and Biophysics, University of California San Francisco, CA 94143, USA
  • Kelsey C Zorn; Department of Biochemistry and Biophysics, University of California San Francisco, CA 94143, USA
  • Luis Rubio; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
  • Sara Bravo; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
  • Joseph J Sabatino; Weill Institute for Neurosciences, Department of Neurology, San Francisco, CA 94158, USA
  • Kristen Mittl; Weill Institute for Neurosciences, Department of Neurology, San Francisco, CA 94158, USA
  • Carina Marquez; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
  • Maya Petersen; Division of Biostatistics, University of California, Berkeley, Berkeley, CA 94720, USA
  • Diane Havlir; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
  • Joseph DeRisi; Department of Biochemistry and Biophysics, University of California San Francisco, CA 94143, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA
Preprint en Inglés | medRxiv | ID: ppmedrxiv-21263095
ABSTRACT
The wide spectrum of SARS-CoV-2 variants with phenotypes impacting transmission and antibody sensitivity necessitates investigation of the immune response to different spike protein versions. Here, we compare the neutralization of variants of concern, including B.1.617.2 (Delta) and B.1.1.529 (Omicron) in sera from individuals exposed to variant infection, vaccination, or both. We demonstrate that neutralizing antibody responses are strongest against variants sharing certain spike mutations with the immunizing exposure. We also observe that exposure to multiple spike variants increases the breadth of variant cross-neutralization. These findings contribute to understanding relationships between exposures and antibody responses and may inform booster vaccination strategies. SUMMARYThis study characterizes neutralization of eight different SARS-CoV-2 variants, including Delta and Omicron, with respect to nine different prior exposures, including vaccination, booster, and infections with Delta, Epsilon, and others. Different exposures were found to confer substantially differing neutralization specificity.
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Texto completo: Disponible Colección: Preprints Base de datos: medRxiv Tipo de estudio: Rct Idioma: Inglés Año: 2021 Tipo del documento: Preprint
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: Disponible Colección: Preprints Base de datos: medRxiv Tipo de estudio: Rct Idioma: Inglés Año: 2021 Tipo del documento: Preprint