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Longitudinal and comparative analysis of humoral response upon COVID-19 vaccination
Salvador Romero-Pinedo; Marina Quesada; Stela Álvarez-Fernández; Asunción Olmo; David Abia; Balbino Alarcón; Pilar Delgado.
Afiliación
  • Salvador Romero-Pinedo; VITRO SA
  • Marina Quesada; VITRO SA
  • Stela Álvarez-Fernández; VITRO SA
  • Asunción Olmo; VITRO SA
  • David Abia; Centro de Biología Molecular Severo Ochoa
  • Balbino Alarcón; Centro de Biología Molecular Severo Ochoa
  • Pilar Delgado; Centro de Biología Molecular Severo Ochoa
Preprint en En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21264762
ABSTRACT
The emergence of COVID-19 has led to a worldwide challenge for the rapid development of vaccines. Several types of safe and effective vaccines have been available in a time frame never seen before. Comparative studies to know the extent of protection and the immune response elicited by the different vaccines are of outstanding utility. Here, as a correlate for protection, we perform a comparative study of the humoral response to three vaccines, ChAdOx1 (Oxford-AstraZeneca), mRNA-1273 (Moderna), and BNT162b2 (Pfizer-BioNTech) by applying a flow cytometry-based highly sensitive method that we had previously developed. We have found that mRNA vaccines (mRNA-1273 and BNT162b2) induce a stronger humoral response that lasts for at least 6 months after vaccination. We also show that only one dose of BNT162b2 is enough to achieve the maximum response in seropositive pre-vaccination donors.
Licencia
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Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Prognostic_studies Idioma: En Año: 2021 Tipo del documento: Preprint
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Prognostic_studies Idioma: En Año: 2021 Tipo del documento: Preprint