An experimental model of chronic rhinosinusitis in rabbits without bacterial inoculation
Acta cir. bras.
; 29(5): 313-319, 05/2014. tab, graf
Article
en En
| VETINDEX
| ID: vti-10269
Biblioteca responsable:
BR1.1
Ubicación: BR68.1
ABSTRACT
Evaluate and compare two different experimental techniques of maxillary sinus ostium occlusion using N-butyl cyanoacrylate in developing chronic histological findings without the inoculation of pathogenic bacteria among rabbits. In a randomized study, sixteen New Zealand rabbits were assigned for occlusion of the right maxillary sinus through a transmaxillary approach or through the roof of the nasal cavity. The contralateral sinus served as a control. After 12 weeks, the animals were sacrificed for blinded histopathological analysis of the maxillary sinus mucosa. Histopathological changes consistent with CRS were found in eight (100%) of the maxillary sinuses approached transmaxillary and three of those through the roof of the nasal cavity (37.5%), p 0.008 and 0.250, respectively, comparing with the control side. Chronic mucosal changes were significantly better induced using the transmaxillary approach (p 0.026). It is possible to induce a model of chronic sinusitis among rabbits with transmaxillary sinus occlusion without bacterial inoculation. This model can be replicated for future cellular studies.(AU)
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Texto completo:
1
Base de datos:
VETINDEX
Asunto principal:
Bacterias
/
Sinusitis Maxilar
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras.
Año:
2014
Tipo del documento:
Article