Sex differences on solid organ histological characteristics after brain death
Acta cir. bras.
; 31(4): 278-285, Apr. 2016. graf, tab, ilus
Article
en En
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| ID: vti-20518
Biblioteca responsable:
BR68.1
Ubicación: BR68.1
ABSTRACT
PURPOSE:
To investigate gender differences in the evolution of the inflammatory process in rats subjected to brain death (BD).METHODS:
Adult Wistar rats were divided into three groups female; ovariectomized female; and male rats. BD was induced using intracranial balloon inflation and confirmed by maximal pupil dilatation, apnea, absence of reflex, and drop of mean arterial pressure. Six hours after BD, histological evaluation was performed in lungs, heart, liver and kidneys, and levels of inflammatory proteins, estrogen, progesterone, and corticosterone were determined in plasma.RESULTS:
In the lungs, females presented more leukocyte infiltration compared to males (p<0.01). Ovariectomized female rat lungs were more hemorrhagic compared to other groups (p<0.001). In the heart, females had higher leukocyte infiltration and tissue edema compared to males (p<0.05). In the liver and kidneys, there were no differences among groups. In female group estradiol and progesterone were sharply reduced 6 hours after BD (p<0.001) to values observed in ovariectomized females and males. Corticosterone levels were similar.CONCLUSIONS:
Sex hormones influence the development of inflammation and the status of organs. The increased inflammation in lungs and heart of female rats might be associated with the acute reduction in female hormones triggered by BD.(AU)Palabras clave
Texto completo:
1
Base de datos:
VETINDEX
Asunto principal:
Muerte Encefálica
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Caracteres Sexuales
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Estradiol
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Inflamación
Límite:
Animals
Idioma:
En
Revista:
Acta cir. bras.
Año:
2016
Tipo del documento:
Article
/
Project document