Apolipoprotein B gene polymorphisms in people in the East Mediterranean area of Turkey
(East. Mediterr. health j).
en Inglés
| WHO IRIS
| ID: who-119390
Biblioteca responsable:
CH1.1
ABSTRACT
Point mutations in the receptor binding domain of low density lipoprotein may increase cholesterol levels in blood. Three mutations of Apo B-100 protein result in defective binding [Arg 3500 ----> [corrected] Gln, Arg 3500 ----> [corrected] Trp and Arg 3531 ----> [corrected] Cys]. We estimated the frequency of Apo B point mutations [codon 3500] C9774T [Arg 3500 ----> [corrected] Trp] and G9775A [Arg 3500 ----> [corrected] Gln] in 179 atherosclerotic, 145 hyperlipidaemic individuals and 272 healthy individuals in the east Mediterranean region of Turkey. Lipid and lipoprotein levels were measured with routine biochemical analyser and Apo B mutation was detected using real-time PCR. Neither mutation was found. In this region, Apo B-100 protein mutations are rare and causes of hyperlipidaemia and atherosclerosis may therefore be unrelated to them
Texto completo:
Disponible
Colección:
Bases de datos de organismos internacionales
Base de datos:
WHO IRIS
Asunto principal:
Apolipoproteínas A
/
Apolipoproteínas B
/
Arteriosclerosis
/
Estudios de Casos y Controles
/
Causalidad
/
Enfermedades Raras
/
Apolipoproteína B-100
/
Frecuencia de los Genes
/
HDL-Colesterol
Idioma:
Inglés
Revista:
East. Mediterr. health j
Año:
2004