Baicalein Inhibits αα-Melanocyte-stimulating Hormonestimulated Melanogenesis via p38 Mitogen-activated Protein Kinase Pathway in B16F10 Mouse Melanoma Cells
Journal of Cancer Prevention
; : 40-46, 2023.
Article
en En
| WPRIM
| ID: wpr-1000798
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WPRO
ABSTRACT
Excessive UVB exposure causes development of both malignant and non-malignant melanoma via the secretion of α-melanocyte-stimulating hormone (α-MSH). We investigated whether baicalein (5,6,7-trihydroxyflavone) could inhibit α-MSH-stimulated melanogenesis. Baicalein prevented UVB- and α-MSH-induced melanin production and attenuated α-MSH-stimulated tyrosinase (monophenol monooxygenase) activity, and expression of tyrosinase and tyrosine-related protein-2. In addition, baicalein prevented melanogenesis and pigmentation via the p38 mitogen-activated protein kinases signaling pathway. These findings suggest that baicalein represents a natural compound for attenuating melanogenesis.
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WPRIM
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En
Revista:
Journal of Cancer Prevention
Año:
2023
Tipo del documento:
Article