Mechanism and Treatment Prospect of Bone Loss in Patients With Inflammatory Bowel Disease / 胃肠病学

ABSTRACT

Inflammatory bowel disease (IBD) has been considered gradually as a systemic disease that could affect many extra-intestinal organs or tissues and cause a variety of extra-intestinal manifestations or complications. Bone loss is one of the common extra-intestinal complications of IBD. IBD patients have an increased risk of osteopenia, osteoporosis and fracture than healthy people. The mechanisms of bone loss in IBD patients include deficiency of calcium and vitamin D, immune, inflammation, dysbiosis of gut microbiota, endocrine hormone, and drug effects. In addition to life style adjustment, nutritional therapy and anti-osteoporosis drugs, immunosuppressant, biological agents, probiotics and fecal microbiota transplantation might be expected to become effective treatments for bone loss in IBD patients. This article reviewed the mechanism and treatment prospect of bone loss in patients with IBD.