Characteristics of Helicobacter pylori-positive Peptic Ulcer From 2013 to 2019 / 胃肠病学

ABSTRACT

Background: Despite the decline in prevalence of Helicobacter pylori infection, peptic ulcer remains a major health burden in China. Aims: To investigate the trends of peptic ulcer in recent years, especially the changes of Helicobacter pylori-positive peptic ulcer, and to provide a theoretical basis for the prevention and treatment of peptic ulcer. Methods: Gender, age, and Helicobacter pylori status of patients diagnosed as peptic ulcer by gastroscopy from January 2013 to December 2019 at Shanghai Renji Hospital were retrospectively reviewed, and clinical and epidemiological characteristics were analyzed. Results: During the study period, peptic ulcer was found in 40 385 of the 383 413 patients undergoing gastroscopy, including gastric ulcer 15 114 patients and duodenal ulcer 25 271 patients. The ratio of male to female of peptic ulcer patients was 2.021. Helicobacter pylori was present in 60.0% of peptic ulcer patients (48.5% in gastric ulcer, 66.9% in duodenal ulcer). The detection rate of Helicobacter pylori-positive peptic ulcer was decreased with the increasing year of patients. The detection rate of Helicobacter pylori-positive gastric ulcer declined from 52.2% to 49.3% during 2013 to 2019, and Helicobacter pylori-positive duodenal ulcer from 70.0% to 63.9%. Conclusions: With the decrease of Helicobacter pylori infection rate, the incidence of Helicobacter pylori-positive peptic ulcer, especially duodenal ulcer, decreased significantly, and the incidence of non-Helicobacter pylori ulcer increased, which should be paid more attention.