Assessment of Di (2-ethylhexyl) Phthalate Exposure by Urinary Metabolites as a Function of Sampling Time / 예방의학회지
Journal of Preventive Medicine and Public Health
; : 301-308, 2010.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-103893
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVES:
In most DEHP exposure assessment studies, single spot urine sample was used. It could not compare the exposure level among studies. Therefore, we are going to represent the necessity of selection of proper sampling time of spot urine for assessing the environmental DEHP exposure, and the association urinary DEHP metabolites with steroid hormones.METHODS:
We collected urine and plasma from 25 men. The urine sampling times were at the end of the shift (post-shift) and the next morning before the beginning of the shift (pre-shift). Three metabolites of DEHP {mono(2-ethylhexyl) phthalate [MEHP], mono-(2-ethyl-5-hydroxyhexyl)phthalate [MEHHP], and mono(2-ethyl-5-oxohexyl)phthalate [MEOHP]} in urine were analyzed by HPLC/MS/MS. Plasma luteinzing hormone, follicle stimulating hormone, testosterone, and 17beta-estradiol were measured at pre-shift using a ELISA kit. A log-transformed creatinine-adjusted urinary MEHP, MEHHP, and MEOHP concentration were compared between the post- and pre-shift. The Pearson's correlation was calculated to assess the relationships between log-transformed urinary MEHP concentrations in pre-shift urine and hormone levels.RESULTS:
The three urinary metabolite concentrations at post-shift were significantly higher than the concentrations in the pre-shift (p<0.0001). The plasma hormones were not significantly correlated with log-transformed creatinine - adjusted DEHP metabolites.CONCLUSIONS:
To assess the environmental DEHP exposure, it is necessary to select the urine sampling time according to the study object. There were no correlation between the concentration of urinary DEHP metabolites and serum hormone levels.
Texto completo:
Disponible
Contexto en salud:
ODS3 - Meta 3.9 Reducir las muertes producidas por productos químicos peligrosos y la contaminación del aire, el agua y el suelo
Problema de salud:
Exposiciones Ocupacionales
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Ácidos Ftálicos
/
Manejo de Especímenes
/
Testosterona
/
Factores de Tiempo
/
Hormona Luteinizante
/
Exposición Profesional
/
Dietilhexil Ftalato
/
Estradiol
/
Hormona Folículo Estimulante
/
Laboratorios Odontológicos
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Journal of Preventive Medicine and Public Health
Año:
2010
Tipo del documento:
Artículo