Efficacy of brief cognitive behavioral therapy on improving quality of life improvement in patients with schizophrenia / 四川精神卫生

ABSTRACT

BackgroundThe course of schizophrenia is prolonged， and patients have impaired social function and significantly reduced quality of life. Drug therapy combined with psychological therapy is particularly important for improving the quality of life of patients. Brief cognitive behavioral therapy （BCBT） has been widely applied in clinical practice， but current research on BCBT focuses more on improving patients' symptoms and lacks relevant reports on improving quality of life. ObjectiveTo evaluate the efficacy and influencing factors of BCBT combined with conventional treatment on improving the quality of life in patients with schizophrenia. MethodsA total of 210 patients who met the diagnostic criteria for schizophrenia in the International Classification of Diseases （10th edition） （ICD-10） and were followed up at the outpatient department of Beijing Anding Hospital Capital Medical University from August 2011 to December 2016 were selected. Using a random number table method， patients were divided into study group and control group， with 105 cases in each group. Both groups received routine treatment， and the research group received a total of 8 BCBT sessions for 12 weeks on this basis. At the baseline period and 12 weeks of treatment， 26 weeks of follow-up and 52 weeks of follow-up， Positive and Negative Syndrome Scale （PANSS）， Personal and Social Performance Scale （PSP） and World Health Organization Quality of Life Brief （WHOQOL-BREF） were used for evaluation. ResultsThe results of repeated measures analysis of variance showed that the time point effect and interaction effect of PANSS total score were statistically significant （F=118.783， 8.083， P<0.01）.The time point effect， inter group effect and interaction effect of PSP total score were statistically significant （F=94.358， 4.048， 5.490， P<0.05 or 0.01）. The time point effect， inter group effect and interaction effect of the total score of WHOQOL-BREF were all statistically significant （F=12.330， 4.168， 4.142， P<0.05 or 0.01） Binary Logistic regression analysis showed that the study group （OR=1.861， 95% CI： 1.004~3.448） and young age （OR=1.044， 95% CI： 1.001~1.088） were protective factors for improving quality of life of patients， while high PANSS baseline score （OR=0.972， 95% CI： 0.945~0.999） was a risk factor for improving quality of life of patients. ConclusionThe combination of BCBT and conventional treatment has an earlier onset of improvement in the quality of life of patients with schizophrenia， and long-term efficacy is superior to conventional treatment.［Funded by Research Projects Supported by Beijing Municipal Commission of Science and Technology （number， Z111107058811078）； Capital Medical Development Fund Joint Research Project （number， 2009-1050）； Beijing Hygienism and Health Science and Technology Achievements and Appropriate Technology Promotion Project （number， TG-2017-38）； www.chictr.org.cn number： ChiCTR-TRC-13003709］