Analysis of clinical characteristics of nerve injury caused by the abuse of nitrous oxide (N2O) / 中风与神经疾病杂志

ABSTRACT

@#Objective　To analyze clinical features of nerve injury caused bythe abuse of nitrous oxide.Methods　We retrospectively analyzed the clinical data of eight patients with nitrous oxide poisoning and summarized their clinical features.Results　Eight patients with nitrous oxide poisoning were all young and middle-aged with a history of exposure to nitrous oxide.Peripheral nervous system was impaired in eight patients,central nervous system was impaired in five patients,autonomic nerve was impaired in two patients,and two patient had neuropsychiatric symptoms.Vitamin B12 deficiency and homocysteine elevation were detected in eight patients.High doses of vitamin B12,methylcobalamin or adenosine cobalamin were effective.Conclusion　Long-term consumption of N2O can lead to megaloblastic anemia,nervous system injury and even fatal.