Rescue therapies for Helicobacter pylori infection after failure of proton pump inhibitor-based standard triple therapy / 대한내과학회지
Korean Journal of Medicine
; : 23-29, 2008.
Artículo
en Coreano
| WPRIM (Pacífico Occidental)
| ID: wpr-118116
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND/AIMS:
Proton pump inhibitor (PPI)-based standard triple therapy for Helicobacter pylori infection is widely used, but it has a considerable failure rate. The aim of this study was to evaluate the efficacy and tolerability of rescue therapies with a quadruple regimen and a rifabutin-based regimen for patients who experienced failure with PPI-based standard triple therapy.METHODS:
From July 2004 through October 2006, 52 patients for whom first line triple therapy (PPI, amoxicillin and clarithromycin) had failed were included in this study. They were treated with a quadruple regimen for 7 days (PPI, bismuth, tetracycline and metronidazole) as a second line therapy. For third line therapy, a rifabutin-based regimen (PPI, rifabutin and amoxicillin) was prescribed for 14 days. The H. pylori status was determined before and at least 4 weeks after therapy by the 13C urea breath test or by endoscopy with antral and corpus biopsies for a rapid urease test, histological examination and culture.RESULTS:
The mean age was 52.6 years. Thirteen patients (25%) of the 52 patients were dropped. The eradication rate of the quadruple therapy was 84.6% (33/39). Three patients of the 6 failures with quadruple therapy were then treated with the rifabutin-based regimen. The eradication rate of the rifabutin-based therapy was 100% (3/3). Adverse effects (10.2%) were reported in 4 patients who were treated with quadruple regimen.CONCLUSIONS:
The quadruple regimen is still an effective second-line therapy for Korean patients who experience failure with PPI-based standard triple therapy. The rifabutin-based regimen could be used as a third-line rescue therapy in Korea.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Compuestos Organometálicos
/
Protones
/
Tetraciclina
/
Urea
/
Ureasa
/
Biopsia
/
Bismuto
/
Pruebas Respiratorias
/
Carbamatos
/
Helicobacter pylori
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2008
Tipo del documento:
Artículo