Analysis of nm23 expression as a prognostic parameter in renal cell carcinoma
Journal of Korean Medical Science
; : 258-262, 1995.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-118208
Biblioteca responsable:
WPRO
ABSTRACT
To identify the clinicopathological events including nm23 expression that underlies progression in renal cell carcinoma, a retrospective analysis of patients with renal cell carcinoma was performed. Ninety-eight cases of radical nephrectomies with extensive regional or para-aortic lymph node dissection were assessed for clinicopathological variables, and eighty-five cases underwent nm23/NDPK-A protein immunohistochemical staining. Significant parameters in survival were tumor size, histologic pattern, Fuhrman's nuclear grade, pathologic T(pT) stage, pathologic N stage, M stage, tumor thrombi, location of metastasis, and nm23 staining intensity. To assess the relationship with survival, the tumors with low and high nm23 expressions were compared. The fifty-nine patients with a high staining intensity had a significantly worse survival than did the twenty-six with a low staining intensity (p = 0.0015). Additionally nm23 staining intensity was correlated with tumor size, Fuhrman's nuclear grade, pT, and distant metastasis. Therefore, the immunostaining intensity of nm23 protein could be used as a prognostic parameter with an inverse correlation.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Factores de Transcripción
/
Carcinoma de Células Renales
/
Nucleósido-Difosfato Quinasa
/
Supervivencia sin Enfermedad
/
Neoplasias Renales
/
Persona de Mediana Edad
/
Estadificación de Neoplasias
Tipo de estudio:
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
1995
Tipo del documento:
Artículo