A case of hypophosphatemic osteomalacia associated with low-dose adefovir dipivoxil treatment / 대한내과학회지
Korean Journal of Medicine
; : 261-265, 2010.
Artículo
en Coreano
| WPRIM (Pacífico Occidental)
| ID: wpr-121796
Biblioteca responsable:
WPRO
ABSTRACT
Adefovir dipivoxil (ADV) effectively inhibits lamivudine-resistant hepatitis B virus replication. Hypophosphatemia and elevated serum creatinine are ADV-related nephrotoxicity caused by high-dose ADV. Hypophosphatemic osteomalacia is very rare and is induced by low-dose ADV. A 61-year-old man suffering from chronic hepatitis B manifested with generalized myalgia and bone pain, especially in both ankles and knees. He had been administered ADV for 56 months, since lamivudine-resistant HBV was detected. He developed severe hypophosphatemia and elevated serum alkaline phosphatase levels with a high bone fraction. Bone densitometry and a whole-body bone scan revealed osteoporosis and multiple hot uptake lesions. Blood chemistry and clinical symptoms improved after discontinuing the ADV.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteomalacia
/
Osteoporosis
/
Estrés Psicológico
/
Adenina
/
Virus de la Hepatitis B
/
Hipofosfatemia
/
Hepatitis B Crónica
/
Creatinina
/
Densitometría
/
Fosfatasa Alcalina
Límite:
Animales
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Medicine
Año:
2010
Tipo del documento:
Artículo