Human Parechovirus as an Important Cause of Central Nervous System Infection in Childhood
Pediatric Infection & Vaccine
; : 165-171, 2016.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-123231
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
Human parechovirus (HPeV) is an increasingly recognized pathogenic cause of central nervous system (CNS) infection in neonates. However, HPeV infections have not been studied in older children. This study determined the prevalence and clinical features of HPeV CNS infection in children in Korea.METHODS:
Reverse transcription polymerase chain reaction assays were performed using HPeV-specific, 5′ untranslated, region-targeted primers to detect HPeV in cerebrospinal fluid (CSF) samples from children presenting with fever or neurologic symptoms from January 1, 2013, to July 31, 2014. HPeV genotyping was performed by sequencing the viral protein 3/1 region. Clinical and laboratory data were retrospectively abstracted from medical records and compared with those of enterovirus (EV)-positive patients from the same period.RESULTS:
Of 102 CSF samples, six (5.9%) were positive for HPeV; two of 21 EV-positive samples were co-infected with HPeV. All samples were genotype HPeV3. Two HPeV-positive patients were <3 months of age and four others were over 1 year old. While HPeV-positive infants under 1 year of age presented with sepsis-like illness without definite neurologic abnormalities, HPeV-positive children over 1 year of age presented with fever and neurologic symptoms such as seizures, loss of consciousness, and gait disturbance. The CSF findings of HPeV-positive patients were mostly within the normal range, whereas most (73.7%) EV-positive patients had pleocytosis.CONCLUSIONS:
Although HPeV is typically associated with disease in young infants, the results of this study suggest that HPeV is an emerging pathogen of CNS infection with neurologic symptoms in older childhood.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Valores de Referencia
/
Convulsiones
/
Inconsciencia
/
Sistema Nervioso Central
/
Infecciones del Sistema Nervioso Central
/
Líquido Cefalorraquídeo
/
Registros Médicos
/
Reacción en Cadena de la Polimerasa
/
Prevalencia
/
Estudios Retrospectivos
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
Límite:
Niño
/
Humanos
/
Lactante
/
Recién nacido
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Pediatric Infection & Vaccine
Año:
2016
Tipo del documento:
Artículo